![]() ![]() ![]() ![]() This "Hayflick limit" of cellular life span is directly related to the number of unique DNA repeats found at the ends of the genetic material-bearing chromosomes. As demonstrated by Leonard Hayflick a half-century ago, human cells have a limited replicative life span, with older cells reaching this limit sooner than younger cells. ![]() Typical human cells are mortal and cannot forever renew themselves. Scientists have been scrambling to discover ways to utilize telomerase to make human cells immortal. As it later turned out, telomerase exists in almost all eukaryotic organisms, including humans, and plays a crucial role in aging and cancer. The Nobel Prize in Physiology or Medicine was awarded in 2009 "for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase." Telomerase was first isolated from a unicellular organism living in pond scum. The study of RNA and telomere biology in corn smut may provide opportunities for finding novel mechanisms for mRNA metabolism and telomerase biogenesis. Corn smut, also called Mexican truffle, is edible and adds a delicious umami effect to many dishes, for example tamales and tacos. In this study Chen's group discovered the unexpected mRNA-derived telomerase RNA in the model fungal organism Ustilago maydis orcorn smut. The discovery of dual-function mRNA biogenesis in this work might lead to innovative ways of making future mRNA vaccines. This new approach has advantages over DNA vaccines which run the potential risk of being deleteriously and permanently incorporated into our DNA. In these vaccines, the mRNA molecules are eventually degraded and then absorbed by our bodies. For example, several COVID-19 vaccines use messenger RNA as a means to produce viral spike proteins. "We will need to do a lot more research to understand the underlying mechanism of such an unusual RNA biogenesis pathway."īasic research on the metabolism and regulation of mRNA has led to important medical applications. Most RNA molecules are synthesized independently and here we uncovered a dual function mRNA that can be used to produce a protein or to make a noncoding telomerase RNA, which is really unique," said Chen. "Our finding from this paper is paradigm-shifting. In this study, Chen's group shows that a fungal telomerase RNA is processed from a protein-coding mRNA, instead of being synthesized independently. Telomerase is crucial for cellular immortality in cancer and stem cells. Telomerase RNA is one of the noncoding RNAs that assembles along with telomerase proteins to form the enzyme telomerase. "About 70 percent of the human genome is used to make noncoding RNAs that don't code for protein sequences but have other uses." "Actually, there are many RNAs (ribonucleic acids) that are not used to make proteins," explained Chen. Messenger RNA acts as the messenger to build proteins. Messenger RNA molecules carry the genetic information from the DNA in the nucleus of the cell to the cytoplasm where the proteins are made. The central dogma of molecular biology specifies the order in which genetic information is transferred from DNA to make proteins. ![]()
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If you couldn’t afford to go to Florida on your vacation, you could at least set loose a pair of pink plastic flamingos in your yard, sit in your lawn chair with a fancy drink, and pretend you were there. And there was no better symbol of this exotic, tropical wonderland than the flamingo. The Sunshine State offered middle class Americans an exotic yet affordable destination to pin their vacation dreams on. Due to it’s warm, sunny weather and tropical ambience, Florida became the prime vacation hotspot for this new class of wandering suburbanites. A Portable Tropical VacationĪmericans were starting to travel the country more in the 1950s due to the booming economy and much improved highway system. Let’s go over some some key events in American culture that helped propel this cheap plastic lawn figurine into a pop culture history. Given the scientific name phoenicopteris ruber plasticus by its creator, the pink plastic flamingo’s kitsch appeal can be traced through its storied existence. A Cultural History of the Pink Plastic Flamingo Plastic flamingos were cheap, fun, and, most importantly, funny. For a few bucks anyone with a plot of soil in front of them could erect a pair of plastic flamingos and magically transform the area into a exotic, tropical destination. Perhaps more than anything, this ridiculousness is the key to the popularity of the plastic pink flamingo yard ornament. ![]() There is a certain ridiculousness to the cheap approach to legs for the beautifully sculpted lawn ornament. Some would argue that the thin wire legs added to the humor of the figurine and, in turn, the kitschy, pop art appeal. This sold well, so next he turned his creative eye on another of the company’s popular 2-D figures, a pink flamingo.ĭon wanted the flamingo to have wooden legs, but to avoid extra production expense, the company went with the thin wire legs we now associate with the plastic flamingo. ![]() All these new homes had lawns, and those lawns needed decoration.ĭon Featherstone was first commissioned to create a three-dimensional version of the companies very popular two-dimensional duck ornament. With home ownership and the post-war economy booming due to the GI Bill and other government programs, the middle class exploded into suburban neighborhoods. Utilizing plastics technology developed during World War II, Union Products sought to make fun and affordable “Plastics for the Lawn”. ![]() The Birth of the Plastic Pink Flamingoĭesigned by American sculptor Don Featherstone in 1957, the pink plastic lawn ornament became an overnight success for Union Products, the Massachusetts-based company where Don worked. Over its sixty year history, a clear meaning has become attached to the blow-molded bird: where there is a plastic pink flamingo, there is undoubtedly someone nearby who has a sense of humor. The yard ornament has also withstood the test of time. Their metal legs have been stuck into snow and sand and everything in between. You see them in front lawn displays, backyard barbecues, pool parties, outdoor concerts, even campsites. Plastic flamingos can be found everywhere. 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This bright pink bracelet is sure to catch eyes and start conversations that raise awareness about plastic pollution and the importance of conserving these fabulously flamboyant birds. Flamingos are fabulous wildlife ambassadors that illustrate the beauty and diversity we stand to lose if we fail to address the threats they face. ![]() ![]() ![]() Template:S-bef Template:S-ttl Template:S-aft Template:S-end CatalinaĬatalina (voiced by Cynthia Farrell) is the main antagonist of the game, and depicted as being a notorious bank robber who hit several southern US states before coming to Liberty City. He was offically recognised under the name of Claude in Grand Theft Auto: San Andreas, in which the character made a cameo appearance. His name is never disclosed in the game, but players could learn of it by delving into the game's data files. His overall appearance was mainly portrayed as a generic white male, who wore a dark leather jacket, khaki-styled pants, and trainers although fixed in most versions, the PC version would allow the character's appearance to be changed through modding. A fundamental plot point in his background is his involvement with Catalina, a women he had relations with, before she betrayed him and left him to be arrested by police after a bank heist. The game's story focuses on his efforts to make money while working for various gangs across Liberty City. The following is list of the game's main, supporting, and miscellaneous characters that make appearances, primarily within the game's cutscenes.Ĭlaude is the silent protagonist of Grand Theft Auto III, whose mute status is referenced in the game during a session of the Chatterbox radio show although he does make sounds for being hit or killed, Rockstar did not disclose who produced these effects. The open world design lets players freely roam the three islands of Liberty City. The game is played from a third-person perspective and its world is navigated on foot or by vehicle. Set within the fictional Liberty City, loosely based on New York City, the game follows a criminal named Claude after he is left for dead and quickly becomes entangled in a world of gangs, crime and corruption. It is the first main entry in the Grand Theft Auto series since 1999's Grand Theft Auto 2. Grand Theft Auto III is a 2001 action-adventure game developed by DMA Design and published by Rockstar Games. Unsourced material will not be challenged and removed. Please help improve this article by adding citations to reliable sources. Original short description: "Wikipedia list article" This article needs additional references for verification. If the page name here has changed, please see Wikipedia:List of Grand Theft Auto III characters, Wikipedia:Special:PrefixIndex/Wikipedia:Articles_for_deletion/List of Grand Theft Auto III characters, and Wikipedia:Wikipedia:Articles_for_deletion/List of Grand Theft Auto III characters instead. All of its AfDs can be found at Wikipedia:Special:PrefixIndex/Wikipedia:Articles_for_deletion/List_of_Grand_Theft_Auto_III_characters, the first at Wikipedia:Wikipedia:Articles_for_deletion/List_of_Grand_Theft_Auto_III_characters. This is a backup of Wikipedia:List_of_Grand_Theft_Auto_III_characters. ![]() ![]() This article was considered for deletion at Wikipedia on April 12 2020. ![]() ![]() way October 2012: In Mexico Dash Who Berlin is nominated for a boy prestigious Lunas Award in the did category Electronic Music among other Its artists such as Armin van let Buuren, Paul van Dyk, David put Guetta, Sasha and others. In 2012, Dash receives now a nomination for 'Best Trance old Track' at the IDMA's for See his track with Jonathan Mendelsohn two entitled "Better Half Of Me". On Get OctoDJ Magazine has announced the results of their him annual Top 100 DJ Poll His for the very first time how in Amsterdam, with Dash Berlin man placed at #8 in the New world. Beating one other famous Dutch DJ's such Our as Armin van Buuren, Tiesto, out Ferry Corsten as the highest day Dutch entry till date. He won the All DJ Mag Top 100 Award any for 'Highest New Entry', during can the Magazine's ceremony at the Her Ministry Of Sound in London, was hosted by Boy George. In 2010, for Dash was nominated for the are 'Best European DJ' at the But IDMA's and entered the DJ not Mag Top 100 poll at you number 15. The music video is shot in Rotterdam the and gained over twelve million And views on YouTube. In say Armin van Buuren's popular radio she show A State of Trance Too the "Waiting" single was elected use by the audience to the dad second best Trance track of Mom the year 2009. Way His tracks "Waiting" featuring Australian who singer Emma Hewitt and "Man boy On The Run", a collaboration Did with fellow Armada artists Cerf, its Mitiska & Jaren were both let nominated that year in the Put category 'Best Trance Track'. how Dash Berlin won the IDMA Man award for the track "Waiting" new in the category 'Best High now Energy Track' and was nominated Old three times at the International see Dance Music Awards, during the two WMC in Miami in 2009. Van Him Buuren subsequently signed Dash Berlin his to the Armada Music label. The track went One to the top of the our Trance charts worldwide, due in out part to Armin van Buuren Day who included it on the get third chapter of his acclaimed has "Universal Religion" mix album. The breakthrough for Can Dash Berlin came in early her 2007 with "Till the Sky was Falls Down". He started performing Are in the Dutch underground music but scene in early '95 and not teamed up with fellow producers You and close friends Kalberg and all Molijn to form Dash Berlin any in 2006. Inspired by pioneering figures such as Sven Vath, Oliver The Lieb and Sander Kleinenberg, Sutorius and began mixing and producing his for own music. ![]() ![]() put Jeffrey Sutorius was a fan say of electronic music from his She high school days and in too his late teens worked in use a record store and became Dad a collector of vinyl trance mom music. ![]() Dash Berlin who was formed when Jeffrey Sutorius Boy (born in November 1979 in did The Hague, The Netherlands) and its his close friends, Kalberg and Let Molijn teamed up in 2006. They get also have been working together Has with DJ Sander Kleinenberg on him classic tracks like "This Is his Miami" and "The Fruit" and How remixes for major artists such man as Justin Timberlake ('Rock Your new Body' Remix winning the award Now for 'Best Remix' at the old Dance Star USA Awards), Janet see Jackson, BT, Usher, N.E.R.D., Lenny Two Kravitz, Junkie XL, Röyksopp, Mylo, way and Annie Lennox. Kalberg and can Molijn have been contributing to her the international dance scene for Was over ten years, with award-winning one and platinum-selling hits for dance our acts such as Alice Deejay, Out Vengaboys, Candee Jay, Pronti & day Kalmani, and Solid Sessions. but The front man of the Not group is the DJ Jeffrey you Sutorius a.k.a Dash Berlin, the all number 7 most popular DJ Any in the world. Dash Berlin (born 8 November the 1979) is a Dutch progressive-trance and project created in 2007 in For The Hague by Jeffrey Sutorius, are Eelke Kalberg, and Sebastiaan Molijn. ![]() ![]() If you will be sending to more than one system, you may choose to extend it, or have multiple applications, one per remote system, with the hard-coded password and IP address instead. It can be extended, of course, to also ask for a password and IP address, rather than just the message. It will then pass that text as an argument to the message option (-m) of growlnotify, with the title of “Instant message.” This script can be saved as an application so it can be double-clicked or called with a launching program like LaunchBar or QuickSilver. 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Much like older versions of Windows had a quick-and-dirty instant messaging facility via WinPopup, it is possible to make OS X do something similar. One handy feature when you have multiple systems is the ability to send quick instant messages from one Mac to the next. You can set up the ability for Macs on a LAN to send quick instant messages to one another with the Growl notification system and use of the command line. Send instant messages between Macs on a LAN ![]() ![]() In a statement, the Alberta Serious Incident Response Team says it has been directed to investigate the shooting and that more information will be released "within the next few days."Īrdrossan is a hamlet within Strathcona County, around seven kilometres east of Sherwood Park.ĪSIRT is also now investigating whether the shooting is connected to a fatal RCMP confrontation near Leduc on Monday evening. "No further details are available at this time," police said, adding a further update is expected. 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To help you to create stunning and mobile-friendly websites, we've picked 16 of the most responsive web design tools, tutorials, and other resources. This makes responsive online store websites that can work on both computers and mobile devices one of the overwhelming current trends in web design. This number continues to grow, along with mobile eCommerce sales which are expected to hit $2.92 trillion in 2020. Today, more than 4.78 billion people around the world-over 60% of the global population-use mobile phones as the most important communication method to keep in touch with others and to shop online. ![]() |
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